The fur-trading industry in Pennsylvania, including the Susquehanna Valley frontier, spanned roughly from 1701 to 1763. One writer describes it as " a strange compound made up of honest men, scheming rogues, misfortunes, rich profits, fierce competition, incredible deception, Indian threats, bold risks, and untold hardships."
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There is a direct genealogical connection between Shikellamy's friend, diplomat, and interpreter Conrad Weiser, and a member of the Lewis and Clark expedition.
The heroic horseback ride of a young girl from the Muncy Valley spared the lives of settlers from an Indian attack in July 1778.
Two brothers from Sunbury, Pennsylvania, having read General George Washington's report to Governor Dinwiddie of Virginia, of the rich lands and valleys that were unoccupied in what is now called Venango and Crawford Counties, determined to explore that region for themselves. They were the first to blaze a trail through what is now Jefferson County.